Product BioVoc

BioVOC Vascularized Organ Chip

Automate the production of your own vascularized tissue model on chip by bioprinting inside the BioVOC Organ Chip.

Bridging Organoids and Organs

The BioVOC organ chip bridges the gap between organoids and tissue-engineered organs for drug screening and safety testing. A bioprinted perfusable microvascular network can be developed on-chip, enabling more realistic drug testing through an active endothelial barrier. Suitable for both healthy and diseased cell islets, it offers a scalable and automatable path to advanced, animal-free tissue models.

    • BioVoc Features

    Droplet-based, bioprinted vascularized tissue models with the potential to paradigm shift the way we produce tissue models for drug screening research.

    • Ultra low material consumption (max. 7 µl) and rapid printing times (1-10 sec) per chamber
    • Joint maturation of cell islets connected by perfusable vasculature on the same chip within 7-28 days
    • Open Chip Design for 3D bioprinting
    • Supports a variety of geometrical arrangements, enabling i. a. invasion assays, barrier models, co-cultures
    • Static and dynamic cultivation possible

    Spheroid structures can be grown directly on chip without having to cultivate, handle and place them beforehand. Multiple spheroids from different cell types can be grown in the same chamber allowing multicellular spheroid-network research.

    Three interconnectable middle chambers with a diameter of 3 mm and a height of 500 µm that can be perfused from two sides for multi-organ experiments on a single chip.

    • Female Luer slip connectors to work with a wide range of perfusion systems
    • Standard microscope slide outer dimensions of 76 mm x 25.5 mm

    The BioVOCs are made from a COP and are delivered in a single sterile packaging together with a transparent foil and a lid or individual luer plugs to seal unused connections.

    The full production of BioVOCs can be automated using robotic systems as shown in Lindner et al., HardwareX, 2024, Volume 19.

    How Close Can Your Models Get to Real Human Tissue?

    With the BioVOC vascularized organ-on-chip, you can study complex, physiologically relevant systems with integrated vascularization.

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